Manipulating Cellular pH Suggests Novel Anticancer Therapy
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Manipulating Cellular pH Suggests Novel Anticancer Therapy
In the 1920s, when the genetic theory of cancer was taking root, German biochemist Otto Warburg (winner of the 1931 Nobel prize in physiology or medicine) proposed that abnormal energy metabolism caused cancer. Cells can generate energy either through oxidative respiration in mitochondria or through glycolysis in the cytoplasm. Warburg showed that tumors have an acidic extracellular environment...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2006
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050010